The ART-Rsp5 ubiquitin ligase network comprises a plasma membrane quality control system that protects yeast cells from proteotoxic stress
Secretory cargo that cannot fold properly in the ER are selectively targeted for removal rei?llinen pizzalapio by a well-studied ER-associated degradation pathway, or ERAD.In contrast, very little is known about post-ER quality control mechanisms for damaged or misfolded integral membrane proteins.Here we describe a quality control function of the